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KMID : 1037120210390010099
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The World Journal of Men′s Health
2021 Volume.39 No. 1 p.99 ~ p.106
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Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes
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Cito Gianmartin
Coccia Maria Elisabetta
Fucci Rossella
Picone Rita
Cocci Andrea
Sessa Maurizio
Sessa Francesco
Rizzello Francesca
Micelli Elisabetta
Trotta Michele
Badolato Laura
Campi Riccardo
Criscuoli Luciana
Serni Sergio
Carini Marco
Natali Alessandro
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Abstract
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Purpose: To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes.
Materials and Methods: A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface antigen (HBsAg)-seropositive men and seronegative partners, while 68 couples were controls with both seronegative men and women. Overall, 134 fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments were performed. As the main outcome measures, on the day of the fresh IVF/ICSI cycle, we assessed seminal parameters Before and after sperm preparation techniques. Two-pronuclear (2PN) fertilization, 1-2-3PN fertilization, cleavage, miscarriage, pregnancy and live birth rates were collected.
Results: No significant differences were found between groups in terms of oocytes retrieved, oocytes injected and embryos obtained (p=0.64, p=0.97, and p=0.40, respectively). The 2PN fertilization rate (FR) was comparable among groups (p=0.51). The 1-2-3PN FR was significantly lower in the HBsAg group than in the control group (66.6% vs. 69.7%, respectively). The clinical pregnancy per cycle, implantation, miscarriage and live birth rate were comparable between the HBsAg group and the control group. The median sperm concentration/ml and total sperm count, measured at baseline and after sperm preparation, was comparable between groups (p>0.05). There was a trend toward significant lower progressive motility (35.0% vs. 55.0%; p<0.05) in the HBsAg group at baseline and after sperm preparation (p<0.05).
Conclusions: HBV infected men have the same chance to became father, compared to seronegative patients.
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KEYWORD
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Anti-hepatitis B antigens, Hepatitis B virus, Infection, Intracytoplasmic sperm injections, In Vitro fertilization, Male infertility
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